The Relevance of Non-excitable Cells for Cardiac Pacemaker Function and Repolarization: Insights from a Microstructure Model Loading Effect of Fibroblast-myocyte Coupling on Resting Potential, Impulse Propagation
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[PDF] [Full Text] [Abstract] , December 1, 2007; 585 (2): 565-578. J. Physiol. J. P. Fahrenbach, R. Mejia-Alvarez and K. Banach The relevance of non-excitable cells for cardiac pacemaker function [PDF] [Full Text] [Abstract] , February 1, 2008; 294 (2): H1010-H1017. Am J Physiol Heart Circ Physiol K. B. Walsh and J. Zhang regulation of a transient outward current by protein kinase C Neonatal rat cardiac fibroblasts express three types of voltage-gated K+ channels: [PDF] [Full Text] [Abstract] , May 1, 2008; 294 (5): H2040-H2052. Am J Physiol Heart Circ Physiol V. Jacquemet and C. S. Henriquez and repolarization: insights from a microstructure model Loading effect of fibroblast-myocyte coupling on resting potential, impulse propagation, [PDF] [Full Text] [Abstract] , August 1, 2009; 297 (2): C339-C351. Am J Physiol Cell Physiol L. C. McSpadden, R. D. Kirkton and N. Bursac connexin type and expression level Electrotonic loading of anisotropic cardiac monolayers by unexcitable cells depends on [PDF] [Full Text] [Abstract] , December 4, 2009; 105 (12): 1164-1176. Circ. Res. C. A. Souders, S. L.K. Bowers and T. A. Baudino Cardiac Fibroblast: The Renaissance Cell
منابع مشابه
Loading effect of fibroblast-myocyte coupling on resting potential, impulse propagation, and repolarization: insights from a microstructure model.
The numerous nonmyocytes present within the myocardium may establish electrical connections with myocytes through gap junctions, formed naturally or as a result of a cell therapy. The strength of the coupling and its potential impact on action potential characteristics and conduction are not well understood. This study used computer simulation to investigate the load-induced electrophysiologica...
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AIMS Existence of myocyte-fibroblast coupling in the human heart is still a controversial question. This study aims at investigating in a biophysical model how much coupling would be necessary to perturb significantly the electrical propagation of the cardiac impulse. METHODS AND RESULTS A one-dimensional model representing a strand of myocytes covered by a layer of fibroblasts was formulated...
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MYOCYTES AND NONMYOCYTES COEXIST in cardiac tissue and contribute to normal myocardial cellular function and structure. Fibroblasts are nonmyocytes, whose main role is to synthesize and maintain the myocardial extracellular matrix. Fibroblasts are numerous in cardiac tissue: it has been estimated that every myocyte is in contact with one or more fibroblasts (14). Recently, there has been renewe...
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It was thought previously that cardiac muscle gap junctions provide low-resistance connections between cells and permit the local-circuit current to flow. Some evidences show that myocardial cells may not require low-resistance connections for successful propagation of the action potential (AP). It seems that some other types of mechanisms must be involved in AP propagation. In this article, we...
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Myocytes have been regarded as the main objectives in most cardiac modeling studies and attracted a lot of attention. Connective tissue cells, such as fibroblasts (Fbs), also play crucial role in cardiac function. This study proposed an integrated myocyte-I sac-Fb electromechanical model to investigate the effect of Fbs and stretch activated ion channel current (I sac) on cardiac electrical exc...
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تاریخ انتشار 2005